Random Force is a Force , of Course , of Coarse : Decomposing Complex Enzyme Kinetics with Surrogate Models

@inproceedings{Calderon2009RandomFI,
  title={Random Force is a Force , of Course , of Coarse : Decomposing Complex Enzyme Kinetics with Surrogate Models},
  author={Christopher P. Calderon},
  year={2009}
}
The temporal autocorrelation (AC) function associated with monitoring order parameters characterizing conformational fluctuations of an enzyme is analyzed using a collection of surrogate models. The surrogates considered are phenomenological stochastic differential equation (SDE) models. It is demonstrated how an ensemble of such surrogate models, each surrogate being calibrated from a single trajectory, indirectly contains information about unresolved conformational degrees of freedom. This… CONTINUE READING