Random, asynchronous, and asymmetric transcriptional activity of enhancer-flanking major immediate-early genes ie1/3 and ie2 during murine cytomegalovirus latency in the lungs.

@article{Grzimek2001RandomAA,
  title={Random, asynchronous, and asymmetric transcriptional activity of enhancer-flanking major immediate-early genes ie1/3 and ie2 during murine cytomegalovirus latency in the lungs.},
  author={Natascha K. A. Grzimek and Doris Dreis and Susanne Schmalz and Matthias Johannes Reddehase},
  journal={Journal of virology},
  year={2001},
  volume={75 6},
  pages={2692-705}
}
The lungs are a major organ site of cytomegalovirus (CMV) pathogenesis, latency, and recurrence. Previous work on murine CMV latency has documented a high load and an even distribution of viral genomes in the lungs after the resolution of productive infection. Initiation of the productive cycle requires expression of the ie1/3 transcription unit, which is… CONTINUE READING