RanGTP mediates nuclear pore complex assembly

@article{Walther2003RanGTPMN,
  title={RanGTP mediates nuclear pore complex assembly},
  author={Tobias C. Walther and Peter Askjaer and Marc Gentzel and Anja Habermann and Gareth Griffiths and Matthias Wilm and Iain W Mattaj and Martin W Hetzer},
  journal={Nature},
  year={2003},
  volume={424},
  pages={689-694}
}
In metazoa, the nuclear envelope breaks down and reforms during each cell cycle. Nuclear pore complexes (NPCs), which serve as channels for transport between the nucleus and cytoplasm, assemble into the reforming nuclear envelope in a sequential process involving association of a subset of NPC proteins, nucleoporins, with chromatin followed by the formation… CONTINUE READING