RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly

@article{Swaminathan2004RanGAP1SUMO1IP,
  title={RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly},
  author={Sowmya Swaminathan and Florian Kiendl and Roman K{\"o}rner and Raffaella Lupetti and Ludger Hengst and Frauke Melchior},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={164},
  pages={965 - 971}
}
The RanGTPase activating protein RanGAP1 has essential functions in both nucleocytoplasmic transport and mitosis. In interphase, a significant fraction of vertebrate SUMO1-modified RanGAP1 forms a stable complex with the nucleoporin RanBP2/Nup358 at nuclear pore complexes. RanBP2 not only acts in the RanGTPase cycle but also is a SUMO1 E3 ligase. Here, we show that RanGAP1 is phosphorylated on residues T409, S428, and S442. Phosphorylation occurs before nuclear envelope breakdown and is… CONTINUE READING

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