RanBPM has proapoptotic activities that regulate cell death pathways in response to DNA damage.

@article{Atabakhsh2009RanBPMHP,
  title={RanBPM has proapoptotic activities that regulate cell death pathways in response to DNA damage.},
  author={Elnaz Atabakhsh and Dawn M Bryce and Karen J. Lefebvre and Caroline Schild-Poulter},
  journal={Molecular cancer research : MCR},
  year={2009},
  volume={7 12},
  pages={
          1962-72
        }
}
Ran-binding protein M (RanBPM) is a nucleocytoplasmic protein previously implicated in various signaling pathways, but whose function remains enigmatic. Here, we provide evidence that RanBPM functions as an activator of apoptotic pathways induced by DNA damage. First, transient expression of RanBPM in HeLa cells induced cell death through caspase activation, and in the long-term, forced expression of RanBPM impaired cell viability. RanBPM COOH-terminal domain stimulated the ability of RanBPM to… CONTINUE READING
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