Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts.

@article{Zhang1999RanGTPSM,
  title={Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts.},
  author={Chuanmao Zhang and Meredith Hughes and Paul R Clarke},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 14)},
  pages={
          2453-61
        }
}
Ran is an abundant GTPase of the Ras superfamily that is highly conserved in eukaryotes. In interphase cells, Ran is mainly nuclear and thought to be predominantly GTP-bound, but it is also present in the cytoplasm, probably GDP-bound. This asymmetric distribution plays an important role in directing nucleocytoplasmic transport. Ran has also been implicated in cell cycle control, including the transition from mitosis to interphase when the compartmentalisation of the nucleus is established… CONTINUE READING

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The use of cell - free extracts of Xenopus eggs for studying DNA replication in vitro

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