Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex.

@article{Ozturk2013RamshackleP,
  title={Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex.},
  author={Nuri Ozturk and Sarah J. VanVickle-Chavez and Lakshmi Akileswaran and Russell N Van Gelder and Aziz Sancar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 13},
  pages={4980-5}
}
Cryptochrome (CRY) is the primary circadian photoreceptor in Drosophila. It resets the circadian clock by promoting light-induced degradation of the clock proteins Timeless and Period, as well as its own proteolysis. The E3 ligases that ubiquitylate Timeless and Period before degradation are known and it is known that Drosophila (d) CRY is degraded by the ubiquitin-proteasome system as well. To identify the E3 ligase for dCRY we screened candidates in S2 cells by RNAi. Knockdown of each of the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Changes in active site histidine hydrogen bonding trigger cryptochrome activation.

Proceedings of the National Academy of Sciences of the United States of America • 2016

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Reaction mechanism of Drosophila cryptochrome.

Proceedings of the National Academy of Sciences of the United States of America • 2011

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

JL Mummery-Widmer
Nature • 2009

Similar Papers

Loading similar papers…