Raman spectroscopy detects distant invasive brain cancer cells centimeters beyond MRI capability in humans.

@article{Jermyn2016RamanSD,
  title={Raman spectroscopy detects distant invasive brain cancer cells centimeters beyond MRI capability in humans.},
  author={Michael Jermyn and Joannie Desroches and Jeanne Mercier and Karl St-Arnaud and Marie C. Guiot and Fr{\'e}d{\'e}ric Leblond and Kevin Petrecca},
  journal={Biomedical optics express},
  year={2016},
  volume={7 12},
  pages={
          5129-5137
        }
}
Surgical treatment of brain cancer is limited by the inability of current imaging capabilities such as magnetic resonance imaging (MRI) to detect the entirety of this locally invasive cancer. This results in residual cancer cells remaining following surgery, leading to recurrence and death. We demonstrate that intraoperative Raman spectroscopy can detect invasive cancer cells centimeters beyond pathological T1-contrast-enhanced and T2-weighted MRI signals. This intraoperative optical guide can… 

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