Raman optical activity comes of age
@article{Barron2004RamanOA, title={Raman optical activity comes of age}, author={Laurence D. Barron * and Lutz Hecht and Iain H. McColl and Ewan W. Blanch}, journal={Molecular Physics}, year={2004}, volume={102}, pages={731 - 744} }
The theory and applications of Raman optical activity (ROA), which measures vibrational optical activity by means of a small difference in the intensity of Raman scattering from chiral molecules in right- and left-circularly polarized incident light or, equivalently, a small circularly polarized component in the scattered light, are briefly reviewed. Thanks to new developments in instrumentation, ROA may be applied to a wide range of chiral molecular species. As well as providing the absolute…
154 Citations
Raman optical activity: An incisive probe of chirality, and of biomolecular structure and behaviour
- Chemistry
- 2006
Raman optical activity: An incisive probe of molecular chirality and biomolecular structure
- Chemistry
- 2007
The development of biomolecular Raman optical activity spectroscopy
- Chemistry
- 2015
Following its first observation over 40 years ago, Raman optical activity (ROA), which may be measured as a small difference in the intensity of vibrational Raman scattering from chiral molecules in…
Calculated Raman optical activity signatures of tryptophan side chains.
- ChemistryChemphyschem : a European journal of chemical physics and physical chemistry
- 2008
By comparing the ROA backscattering spectra of different viral coat proteins, Blanch et al. suggested that a ROA band at 1550 cm, which is assigned to the W3 vibration of the indole ring in tryptophan, can be used to determine the absolute stereochemistry of the tryptophile side chain.
Raman optical activity of proteins, carbohydrates and glycoproteins.
- ChemistryChirality
- 2006
The many structure-sensitive bands in protein ROA spectra are favorable for applying pattern recognition techniques, illustrated here using nonlinear mapping, to determine structural relationships between different proteins.
Structure and behaviour of biomolecules from Raman optical activity.
- ChemistryCurrent opinion in structural biology
- 2006
Hyper-Raman optical activity of biologically relevant chiral molecules
- ChemistryOPTO
- 2020
The optical activity of Raman scattering provides insight into the absolute configuration and conformation of chiral molecules. Applications of Raman optical activity (ROA) are limited by long…
Theoretical study of the Raman optical activity spectra of 3(10)-helical polypeptides.
- Chemistry, PhysicsChemphyschem : a European journal of chemical physics and physical chemistry
- 2011
A theoretical investigation of the ROA spectra of a series of 3(10)-helical polypeptides is presented and the effect of chain length, C(α)-substitution pattern, the introduction of larger aliphatic side chains, and the variation of their conformation on the ROa spectra is studied.
Chiral Raman and Single Molecule Spectroscopy
- Chemistry
- 2009
Chiral Raman spectroscopy, widely known as Raman optical activity (ROA), is a vibrational tool, which besides information on structure and folding of molecules, provides information on their…
References
SHOWING 1-10 OF 85 REFERENCES
Solution structure and dynamics of biomolecules from Raman optical activity.
- ChemistryProgress in biophysics and molecular biology
- 2000
Structure and behaviour of proteins, nucleic acids and viruses from vibrational Raman optical activity
- Chemistry
- 2003
On account of its sensitivity to chirality Raman optical activity (ROA), which may be measured as a small difference in vibrational Raman scattering from chiral molecules in right- and…
Infrared and Raman vibrational optical activity: theoretical and experimental aspects.
- ChemistryAnnual review of physical chemistry
- 1997
Applications of VOA now include all major classes of biological and pharmaceutical molecules, and its importance as a diagnostic tool will likely grow as the control of molecular chirality increases in research and industrial areas.
Molecular structures of viruses from Raman optical activity.
- ChemistryThe Journal of general virology
- 2002
A vibrational Raman optical activity (ROA) study of a range of different structural types of virus has revealed that, on account of its sensitivity to chirality, ROA is an incisive probe of their aqueous solution structures at the molecular level.
Introductory Lecture The Theoretical Background to Vibrational Optical Activity
- Chemistry, Physics
- 1994
The difference in the response of a chiral molecule to left and right circularly polarized light is proportional to d/λ times the total response, where d is a typical internuclear distance and λ the…
Raman Optical Activity of a Purelyσ-Bonded Helical Chromophore: (−)-(M)-σ-[4]Helicene
- Chemistry
- 2001
The recent synthesis of enantiomerically pure (−)-(M)-σ-[4]helicene has provided an archetype helical model system for vibrational optical activity, comparable to what π-helicenes represent in the…
Vibrational Raman optical activity in forward scattering: Trans‐pinane and β‐pinene
- Chemistry
- 1990
The first measurements of vibrational Raman optical activity (ROA) have been performed employing a forward scattering geometry. Forward-scattered ROA spectra of (+)-trans-pinane and (−)-β-pinene are…
Theory of natural Raman optical activity
- Physics
- 1991
A complete theory of natural circular polarization Raman optical activity (ROA) is presented that, for the first time, includes explicit dependence on the polarization and propagation vectors of the…