Raman optical activity comes of age

@article{Barron2004RamanOA,
  title={Raman optical activity comes of age},
  author={Laurence D. Barron * and Lutz Hecht and Iain H. McColl and Ewan W. Blanch},
  journal={Molecular Physics},
  year={2004},
  volume={102},
  pages={731 - 744}
}
The theory and applications of Raman optical activity (ROA), which measures vibrational optical activity by means of a small difference in the intensity of Raman scattering from chiral molecules in right- and left-circularly polarized incident light or, equivalently, a small circularly polarized component in the scattered light, are briefly reviewed. Thanks to new developments in instrumentation, ROA may be applied to a wide range of chiral molecular species. As well as providing the absolute… 
The development of biomolecular Raman optical activity spectroscopy
Following its first observation over 40 years ago, Raman optical activity (ROA), which may be measured as a small difference in the intensity of vibrational Raman scattering from chiral molecules in
Calculated Raman optical activity signatures of tryptophan side chains.
TLDR
By comparing the ROA backscattering spectra of different viral coat proteins, Blanch et al. suggested that a ROA band at 1550 cm, which is assigned to the W3 vibration of the indole ring in tryptophan, can be used to determine the absolute stereochemistry of the tryptophile side chain.
Raman optical activity of proteins, carbohydrates and glycoproteins.
TLDR
The many structure-sensitive bands in protein ROA spectra are favorable for applying pattern recognition techniques, illustrated here using nonlinear mapping, to determine structural relationships between different proteins.
Structure and behaviour of biomolecules from Raman optical activity.
  • L. Barron
  • Chemistry
    Current opinion in structural biology
  • 2006
Hyper-Raman optical activity of biologically relevant chiral molecules
The optical activity of Raman scattering provides insight into the absolute configuration and conformation of chiral molecules. Applications of Raman optical activity (ROA) are limited by long
Theoretical study of the Raman optical activity spectra of 3(10)-helical polypeptides.
  • C. Jacob
  • Chemistry, Physics
    Chemphyschem : a European journal of chemical physics and physical chemistry
  • 2011
TLDR
A theoretical investigation of the ROA spectra of a series of 3(10)-helical polypeptides is presented and the effect of chain length, C(α)-substitution pattern, the introduction of larger aliphatic side chains, and the variation of their conformation on the ROa spectra is studied.
Chiral Raman and Single Molecule Spectroscopy
Chiral Raman spectroscopy, widely known as Raman optical activity (ROA), is a vibrational tool, which besides information on structure and folding of molecules, provides information on their
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