Raman optical activity comes of age

  title={Raman optical activity comes of age},
  author={Laurence D. Barron * and Lutz Hecht and Iain H. McColl and Ewan W. Blanch},
  journal={Molecular Physics},
  pages={731 - 744}
The theory and applications of Raman optical activity (ROA), which measures vibrational optical activity by means of a small difference in the intensity of Raman scattering from chiral molecules in right- and left-circularly polarized incident light or, equivalently, a small circularly polarized component in the scattered light, are briefly reviewed. Thanks to new developments in instrumentation, ROA may be applied to a wide range of chiral molecular species. As well as providing the absolute… 
The development of biomolecular Raman optical activity spectroscopy
Following its first observation over 40 years ago, Raman optical activity (ROA), which may be measured as a small difference in the intensity of vibrational Raman scattering from chiral molecules in
Calculated Raman optical activity signatures of tryptophan side chains.
By comparing the ROA backscattering spectra of different viral coat proteins, Blanch et al. suggested that a ROA band at 1550 cm, which is assigned to the W3 vibration of the indole ring in tryptophan, can be used to determine the absolute stereochemistry of the tryptophile side chain.
Raman optical activity of proteins, carbohydrates and glycoproteins.
The many structure-sensitive bands in protein ROA spectra are favorable for applying pattern recognition techniques, illustrated here using nonlinear mapping, to determine structural relationships between different proteins.
Structure and behaviour of biomolecules from Raman optical activity.
  • L. Barron
  • Chemistry
    Current opinion in structural biology
  • 2006
Hyper-Raman optical activity of biologically relevant chiral molecules
The optical activity of Raman scattering provides insight into the absolute configuration and conformation of chiral molecules. Applications of Raman optical activity (ROA) are limited by long
Theoretical study of the Raman optical activity spectra of 3(10)-helical polypeptides.
  • C. Jacob
  • Chemistry, Physics
    Chemphyschem : a European journal of chemical physics and physical chemistry
  • 2011
A theoretical investigation of the ROA spectra of a series of 3(10)-helical polypeptides is presented and the effect of chain length, C(α)-substitution pattern, the introduction of larger aliphatic side chains, and the variation of their conformation on the ROa spectra is studied.
Chiral Raman and Single Molecule Spectroscopy
Chiral Raman spectroscopy, widely known as Raman optical activity (ROA), is a vibrational tool, which besides information on structure and folding of molecules, provides information on their


Structure and behaviour of proteins, nucleic acids and viruses from vibrational Raman optical activity
On account of its sensitivity to chirality Raman optical activity (ROA), which may be measured as a small difference in vibrational Raman scattering from chiral molecules in right- and
Infrared and Raman vibrational optical activity: theoretical and experimental aspects.
  • L. Nafie
  • Chemistry
    Annual review of physical chemistry
  • 1997
Applications of VOA now include all major classes of biological and pharmaceutical molecules, and its importance as a diagnostic tool will likely grow as the control of molecular chirality increases in research and industrial areas.
Molecular structures of viruses from Raman optical activity.
A vibrational Raman optical activity (ROA) study of a range of different structural types of virus has revealed that, on account of its sensitivity to chirality, ROA is an incisive probe of their aqueous solution structures at the molecular level.
Unfolded proteins studied by Raman optical activity.
Introductory Lecture The Theoretical Background to Vibrational Optical Activity
The difference in the response of a chiral molecule to left and right circularly polarized light is proportional to d/λ times the total response, where d is a typical internuclear distance and λ the
Raman Optical Activity of a Purelyσ-Bonded Helical Chromophore: (−)-(M)-σ-[4]Helicene
The recent synthesis of enantiomerically pure (−)-(M)-σ-[4]helicene has provided an archetype helical model system for vibrational optical activity, comparable to what π-helicenes represent in the
Vibrational Raman optical activity in forward scattering: Trans‐pinane and β‐pinene
The first measurements of vibrational Raman optical activity (ROA) have been performed employing a forward scattering geometry. Forward-scattered ROA spectra of (+)-trans-pinane and (−)-β-pinene are
Theory of natural Raman optical activity
A complete theory of natural circular polarization Raman optical activity (ROA) is presented that, for the first time, includes explicit dependence on the polarization and propagation vectors of the