RamA, a protein required for reductive activation of corrinoid-dependent methylamine methyltransferase reactions in methanogenic archaea.

@article{Ferguson2009RamAAP,
  title={RamA, a protein required for reductive activation of corrinoid-dependent methylamine methyltransferase reactions in methanogenic archaea.},
  author={Tsuneo K Ferguson and Jitesh A. Soares and Tanja Lienard and Gerhard Gottschalk and Joseph Adrian Krzycki},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 4},
  pages={2285-95}
}
Archaeal methane formation from methylamines is initiated by distinct methyltransferases with specificity for monomethylamine, dimethylamine, or trimethylamine. Each methylamine methyltransferase methylates a cognate corrinoid protein, which is subsequently demethylated by a second methyltransferase to form methyl-coenzyme M, the direct methane precursor. Methylation of the corrinoid protein requires reduction of the central cobalt to the highly reducing and nucleophilic Co(I) state. RamA, a 60… CONTINUE READING
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