Raltegravir with optimized background therapy for resistant HIV-1 infection.

@article{Steigbigel2008RaltegravirWO,
  title={Raltegravir with optimized background therapy for resistant HIV-1 infection.},
  author={Roy T. Steigbigel and David A. Cooper and Princy N. Kumar and Joseph E Eron and Mauro Schechter and Martin H. Markowitz and Mona Loutfy and Jeffrey L Lennox and Josep Mar{\'i}a Gatell and J{\"u}rgen K. Rockstroh and Christine Katlama and Patrick G Yeni and Adriano Lazzarin and Bonaventura Clotet and Jing Zhao and Joshua Chen and D. M. Ryan and Rand R. Rhodes and John A Killar and Lucinda R Gilde and Kim M. Strohmaier and Anne R. Meibohm and Michael D. Miller and Daria Hazuda and Michael L. Nessly and Mark J. Dinubile and Robin D. Isaacs and Bach Yen Nguyen and Hedy Teppler},
  journal={The New England journal of medicine},
  year={2008},
  volume={359 4},
  pages={
          339-54
        }
}
BACKGROUND Raltegravir (MK-0518) is an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase active against HIV-1 susceptible or resistant to older antiretroviral drugs. METHODS We conducted two identical trials in different geographic regions to evaluate the safety and efficacy of raltegravir, as compared with placebo, in combination with optimized background therapy, in patients infected with HIV-1 that has triple-class drug resistance in whom antiretroviral therapy had failed… Expand

Paper Mentions

Interventional Clinical Trial
This is a multicenter, single arm, 96-week open-label study of the safety and virologic efficacy of fixed dose combination Dolutegravir/Lamivudine/Abacavir (DTG/3TC/ABC FDC… Expand
ConditionsAcute HIV Infection, HIV
InterventionDrug
Observational Clinical Trial
This will be a retrospective analysis of efficacy, safety and tolerability of raltegravir as part of an optimized therapy in a clinical setting. Follow-up is calculated from… Expand
ConditionsHIV Infections
Interventional Clinical Trial
This study will investigate the safety and efficacy of raltegravir as a therapy for Human Immunodeficiency Virus (HIV)-infected patients failing current therapy with 3-class antiviral… Expand
ConditionsHIV Infections
InterventionDrug
Interventional Clinical Trial
This study will investigate the safety and efficacy of raltegravir as a therapy for HIV-infected patients failing current therapy with 3-class antiviral resistance.  
ConditionsHIV Infections
InterventionDrug
Raltegravir: the first HIV type 1 integrase inhibitor.
  • C. Hicks, R. Gulick
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2009
TLDR
Raltegravir is the first approved human immunodeficiency virus type 1 (HIV-1) integrase inhibitor; it targets the strand transfer step of HIV-1 integration and is metabolized by glucuronidation, not hepatically; thus, the potential for drug-drug interactions is decreased. Expand
Raltegravir: The evidence of its therapeutic value in HIV-1 infection
TLDR
Raltegravir shows significant and sustained virologic and immunologic response in combination with other antiretrovirals in treatment-experienced HIV-1 infected patients who show evidence of viral replication or multidrug-resistant HIV- 1 strains, without any significant tolerability issues. Expand
Cost–effectiveness of raltegravir in HIV/AIDS
TLDR
It is suggested that raltegravir, combined with optimized background therapy, falls within the range that would generally be considered cost effective compared with optimized therapy alone in Spanish, Swiss and UK health systems. Expand
Raltegravir as functional monotherapy leads to virological failure and drug resistance in highly treatment-experienced HIV-infected patients
TLDR
If persistent low viraemia is observed over more than 48 weeks without the emergence of resistance, RAL should never be given as functional monotherapy, as it is associated with a maximal risk of VF and the emergenceof RAL resistance. Expand
Similar Efficacy of Raltegravir When Used With or Without a Protease Inhibitor in Treatment-Experienced Patients
TLDR
In treatment-experienced patients, the combination of raltegravir with a regimen not containing a PI had similar virologic activity when compared to more standard regimens using ralgegravIR with a PI, and the main determinant of efficacy was the number of active drugs as measured by GSS. Expand
Safety and Efficacy of Dolutegravir in Treatment-Experienced Subjects With Raltegravir-Resistant HIV Type 1 Infection: 24-Week Results of the VIKING Study
TLDR
These data are the first clinical demonstration of the activity of any integrase inhibitor in subjects with HIV-1 resistant to RAL, and dolutegravir 50 mg twice daily with an optimized background provided greater and more durable benefit than the once-daily regimen. Expand
Switch from enfuvirtide to raltegravir in virologically suppressed multidrug-resistant HIV-1-infected patients: a randomized open-label trial.
  • N. de Castro, J. Braun, +11 authors J. Molina
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2009
TLDR
A switch to raltegravir was safe, well tolerated, and virologically non-inferior to the maintenance of enfuvirtide in patients infected with multidrug-resistant HIV-1 infection who were receiving suppressive antiretroviral therapy. Expand
Raltegravir dosage adjustment in HIV-infected patients receiving etravirine.
  • V. Do, R. Higginson, P. Fulco
  • Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2011
TLDR
In patients who have an extensive history of HIV disease treatment, prescribing raltegravir 1200 mg/day, rather than the standard 800 mg/ day, may be prudent to prevent the development of treatment-resistant virus and to achieve an optimal virological response. Expand
Extended use of raltegravir in the treatment of HIV-1 infection: optimizing therapy
TLDR
Raltegravir improved the clinical management of HIV-1 infection both in antiretroviral-naïve and in antiresistant patients, and had a favorable safety and tolerability profile. Expand
Virologic Outcomes of Changing Enfuvirtide to Raltegravir in HIV-1 Patients Well Controlled on an Enfuvirtide Based Regimen: 24-Week Results of the CHEER Study
TLDR
In treatment-experienced patients on a stable virologically suppressive enfUVirtide-containing regimen, raltegravir can safely be substituted for enfuvirtide in HIV-1-infected patients. Expand
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