Raltegravir (MK-0518): an integrase inhibitor for the treatment of HIV-1.

  title={Raltegravir (MK-0518): an integrase inhibitor for the treatment of HIV-1.},
  author={Teresa Hope Evering and Martin Markowitz},
  journal={Drugs of today},
  volume={43 12},
In the developed world, access to highly active antiretroviral therapy (HAART) has led to significant reductions in the morbidity and mortality attributed to HIV/AIDS. However, the continual emergence of HIV-1 strains resistant to currently available classes of antiretrovirals highlights the need to develop agents with novel mechanisms of action. Successful completion of the HIV-1 viral life cycle depends in part on the integration of complementary DNA mediated by the enzyme HIV-1 integrase… CONTINUE READING
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