Raloxifene induces neurite outgrowth in estrogen receptor positive PC12 cells.

@article{Nilsen1998RaloxifeneIN,
  title={Raloxifene induces neurite outgrowth in estrogen receptor positive PC12 cells.},
  author={Jay Nilsen and Gil Mor and Frederick Naftolin},
  journal={Menopause},
  year={1998},
  volume={5 4},
  pages={211-6}
}
OBJECTIVE It is well established that gonadal steroids have direct in vivo and in vitro effects on neurons. To further study these effects, we used rat PC 12 cells to examine the effects of estrogen receptor (ER) ligands on neuronal morphology. DESIGN PC 12 cells constitutively express ER beta, but only strongly express ER alpha after long-term priming with nerve growth factor (NGF). We therefore primed PC12 cells with NGF for 14 days before testing them for estradiol (10(-9)M)- and/or… CONTINUE READING