Raloxifene as an adjunctive treatment for postmenopausal women with schizophrenia: a meta-analysis of randomized controlled trials

@article{Wang2017RaloxifeneAA,
  title={Raloxifene as an adjunctive treatment for postmenopausal women with schizophrenia: a meta-analysis of randomized controlled trials},
  author={Qi Wang and Xiaomei Dong and Yan Wang and Xiaobai Li},
  journal={Archives of Women's Mental Health},
  year={2017},
  volume={21},
  pages={31-41}
}
The aim of this study is to meta-analytically assess the efficacy and safety of adjunctive raloxifene for postmenopausal women with schizophrenia. Six studies with 440 patients, including 225 (51.14%) patients on raloxifene and 215 (48.86%) on placebo who completed 13.71 ± 5.09 weeks of treatment, were included in this study. Meta-analysis of Positive and Negative Syndrome Scale total scores and positive, negative, and general symptom scores [standard mean difference (SMD) −0.22 to −0.55, 95… 
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11 Citations
Background Citations
2
Results Citations
1

11 Citations

The effect of raloxifene augmentation in men and women with a schizophrenia spectrum disorder: a systematic review and meta-analysis

TLDR
The potential of raloxifene augmentation in the treatment of schizophrenia is confirmed, and no significant effects were found for comorbid depression and cognitive functioning.

Peri- and Post-Menopausal Women with Schizophrenia and Related Disorders Are a Population with Specific Needs: A Narrative Review of Current Theories

TLDR
Antipsychotic dose adjustment at menopause is recommended for schizophrenia and raloxifene may play an important role in permitting dose reduction and lessening adverse effects.

Pharmacotherapy for schizophrenia in postmenopausal women

TLDR
Estrogen modulators may not help all symptoms of schizophrenia but are, nevertheless, relatively safe and, when used as adjuncts, help to keep antipsychotic doses low, thus reducing the side effect burden.

Specificity proteins 1 and 4 in peripheral blood mononuclear cells in postmenopausal women with schizophrenia: a 24-week double-blind, randomized, parallel, placebo-controlled trial

TLDR
Investigation of changes in SP1 and SP4 protein levels in peripheral blood mononuclear cells suggests that SP4 may be involved in raloxifene symptom improvement in postmenopausal women and could be a potential candidate for future studies investigating blood-based biomarkers for ral oxifene effectiveness.

Estrogens and SERMS as adjunctive treatments for schizophrenia

The association between hormones and antipsychotic use: a focus on postpartum and menopausal women

TLDR
It is indicated that, within standard dose ranges, the combination of hormones and antipsychotics for postnatal and menopausal women suffering severe mental distress can be beneficial, and is safe.

Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review

TLDR
The effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in postmenopausal women with schizophrenia are explored.

Gaps or links between hormonal therapy and schizophrenia? (Review)

TLDR
This mini-review is focused on the role of estrogen in the evolution of schizophrenia and on reporting trials that showed how hormonal therapy can improve the outcome of patients with schizophrenia.

Bazedoxifene – a promising brain active SERM that crosses the blood brain barrier and enhances spatial memory

Risk for midlife psychosis in women: critical gaps and opportunities in exploring perimenopause and ovarian hormones as mechanisms of risk

Abstract Women show a heightened risk for psychosis in midlife that is not observed in men. The menopausal transition (i.e. perimenopause) and accompanying changes in ovarian hormones are theorized…

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