Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase.

@article{Simoncini2000RaloxifeneAS,
  title={Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase.},
  author={Tommaso Simoncini and Andrea Riccardo Genazzani},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 8},
  pages={
          2966-9
        }
}
Raloxifene is a selective estrogen receptor modulator (SERM) clinically effective for the prevention of postmenopausal osteoporosis. Estrogen's effect on cardiovascular diseases is mainly dependent on direct actions on the vascular wall. Since raloxifene has an endothelium-dependent relaxing effect, we studied the effects of this molecule on nitric oxide (NO) release from cultured human umbilical vein endothelial cells. Clinically effective concentrations of the compound triggered a rapid and… CONTINUE READING
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