Raloxifene Treatment Is Associated With Increased Serum Estradiol and Decreased Bone Remodeling in Healthy Middle‐Aged Men With Low Sex Hormone Levels

@article{Uebelhart2004RaloxifeneTI,
  title={Raloxifene Treatment Is Associated With Increased Serum Estradiol and Decreased Bone Remodeling in Healthy Middle‐Aged Men With Low Sex Hormone Levels},
  author={B Uebelhart and François R. Herrmann and Imre P{\'a}v{\'o} and Michael W. Draper and Ren{\'e} Rizzoli},
  journal={Journal of Bone and Mineral Research},
  year={2004},
  volume={19}
}
In healthy middle‐aged men, raloxifene treatment was associated with increased serum estradiol and decreased biochemical markers of bone turnover in subjects with estradiol levels below a threshold of 101.8 pM. 
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Clinical and experimental evidence that estrogens are essential for bone accrual in the growing skeleton, maintenance of bone mass and prevention of bone loss in men are summarized.
Effects of the SERM raloxifene on calcium and phosphate metabolism in healthy middle-aged men.
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  • 2009
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  • S. Khosla
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2015
TLDR
There is now considerable evidence from observational and interventional studies that estrogen is the dominant regulator of bone metabolism in men, and a legitimate argument can be made that testosterone is largely a prohormone for the skeleton, with its effects on bone mediated principally via aromatization to estrogen.
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The effects of SERMs on bone mineral density (BMD)/content (BMC), bone histomorphometry, bone turnover, bone strength and fracture risk have been summarized in this review.
Modulation of bone turnover in orchidectomized rats treated with raloxifene and risedronate
TLDR
It is concluded that orchidectomy induced osteoporosis and increased bone turnover in male rats because of withdrawal of sex hormones.
Raloxifene preserves phenytoin and sodium valproate induced bone loss by modulating serum estradiol and TGF-β3 content in bone of female mice.
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