Raloxifene, estrogen, and alendronate affect the processes of fracture repair differently in ovariectomized rats.

@article{Cao2002RaloxifeneEA,
  title={Raloxifene, estrogen, and alendronate affect the processes of fracture repair differently in ovariectomized rats.},
  author={Yongping Cao and Satoshi Mori and Tasuku Mashiba and Michael S. Westmore and Linda Ma and Masahiko Sato and Tomoyuki Akiyama and Liping Shi and Satoshi Komatsubara and Kensaku Miyamoto and Hiromichi Norimatsu},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2002},
  volume={17 12},
  pages={2237-46}
}
We investigated the effects of inhibitors of bone resorption (estrogen, raloxifene, and alendronate) on the processes of fracture repair in ovariectomized (OVX) rats. One hundred forty female Sprague-Dawley rats at 3 months of age were either OVX or sham-operated and divided into five groups: sham control, OVX control, estrogen (17alpha-ethynyl estradiol [EE2], 0.1 mg/kg), raloxifene (Rlx, 1.0 mg/kg), and alendronate (Aln, 0.01 mg/kg) groups. Treatment began immediately after the surgery. Four… CONTINUE READING
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