RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity.

@article{Frankel2005RalAIW,
  title={RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity.},
  author={Paul Frankel and Ami Aronheim and Emma Kavanagh and Maria Susana Balda and Karl Matter and Tom D. Bunney and Christopher J. Marshall},
  journal={The EMBO journal},
  year={2005},
  volume={24 1},
  pages={54-62}
}
Ral proteins are members of the Ras superfamily of small GTPases and are involved in signalling pathways for actin cytoskeleton remodelling, cell cycle control, cellular transformation and vesicle transport. To identify novel RalA effector proteins, we used the reverse Ras recruitment system and found that RalA interacts with a Y-box transcription factor, ZO-1-associated nucleic acid-binding protein (ZONAB), in a GTP-dependent manner. The amount of the RalA-ZONAB complex increases as epithelial… CONTINUE READING

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