RalA functions as an indispensable signal mediator for the nutrient-sensing system.

@article{Maehama2008RalAFA,
  title={RalA functions as an indispensable signal mediator for the nutrient-sensing system.},
  author={Tomohiko Maehama and Masahiko Tanaka and Hiroshi Nishina and Makoto Murakami and Yasunori Kanaho and Kentaro Hanada},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 50},
  pages={35053-9}
}
Cells sense nutrients present in the extracellular environment and modulate the activities of intracellular signaling systems in response to nutrient availability. This study demonstrates that RalA and its activator RalGDS participate in nutrient sensing and are indispensable for activation of mammalian target of rapamycin complex 1 (mTORC1) induced by extracellular nutrients. Knockdown of RalA or RalGDS abolished amino acid- and glucose-induced mTORC1 activation, as judged by phosphorylation… CONTINUE READING

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