RalA-Exocyst Complex Regulates Integrin-Dependent Membrane Raft Exocytosis and Growth Signaling

@article{Balasubramanian2010RalAExocystCR,
  title={RalA-Exocyst Complex Regulates Integrin-Dependent Membrane Raft Exocytosis and Growth Signaling},
  author={Nagaraj Balasubramanian and Jeremy A Meier and David G. W. Scott and Andr{\'e}s Norambuena and Michael A. White and Martin A Schwartz},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={75-79}
}
Anchorage dependence of cell growth is a key metastasis-suppression mechanism that is mediated by effects of integrins on growth signaling pathways. The small GTPase RalA is activated in metastatic cancers through multiple mechanisms and specifically induces anchorage independence. Loss of integrin-mediated adhesion triggers caveolin-dependent internalization of cholesterol- and sphingolipid-rich lipid raft microdomains to the recycling endosomes; these domains serve as platforms for many… CONTINUE READING