Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission.

@article{Wu2004RajiBC,
  title={Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission.},
  author={Li Wu and Thomas David Martin and Mary N Carrington and Vineet N Kewalramani},
  journal={Virology},
  year={2004},
  volume={318 1},
  pages={17-23}
}
A number of studies examining interactions of dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) with viral pathogens have relied on monocytic transfectants as models for primary DCs. Here we show that the presumed "THP-1" monocytic cells used in these studies are instead Raji B cells. Moreover, we demonstrate that true THP-1 cells do not support DC-SIGN-mediated HIV-1 transmission, whereas human B cell lines efficiently enhance this process. These data indicate that there are… CONTINUE READING

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