Raised plasma nerve growth factor levels associated with early-stage romantic love

@article{Emanuele2006RaisedPN,
  title={Raised plasma nerve growth factor levels associated with early-stage romantic love},
  author={Enzo Emanuele and Pierluigi Politi and Marika Bianchi and Piercarlo Minoretti and Marco Bertona and Diego Geroldi},
  journal={Psychoneuroendocrinology},
  year={2006},
  volume={31},
  pages={288-294}
}
Our current knowledge of the neurobiology of romantic love remains scanty. In view of the complexity of a sentiment like love, it would not be surprising that a diversity of biochemical mechanisms could be involved in the mood changes of the initial stage of a romance. In the present study, we have examined whether the early romantic phase of a loving relationship could be associated with alterations in circulating levels of neurotrophins (NTs). Plasma levels of NGF, BDNF, NT-3 and NT-4 were… 
NGF and romantic love.
  • E. Emanuele
  • Psychology, Medicine
    Archives italiennes de biologie
  • 2011
TLDR
A positive association between the intensity of early romantic feelings and serum levels of nerve growth factor has been identified and these findings link love with biologically relevant pathways for neuron survival and illuminate the biochemical correlates of such a complex feeling that so deeply affects the authors' own lives.
An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
TLDR
The data suggest that direct modulation of the serotonergic system may have use for the treatment of psychological suffering associated with unreciprocated romantic love.
The NGF saga: From animal models of psychosocial stress to stress-related psychopathology
TLDR
Evidence suggesting a role for neurotrophins as multifunctional signaling molecules activated during allostatic responses to stressful events and their involvement in the complex pathophysiology underlying stress-related psychopathology is discussed.
CortiLove: A pilot study on hair steroids in the context of being in love and separation
TLDR
This is the first study showing that compared to women in long-term relationships, infatuation, separation, and single groups exhibit higher levels of physiological, but not necessarily self-reported indicators of distress, in the context of the stress-buffering effect of relationships.
Changes in plasma levels of BDNF and NGF reveal a gender-selective vulnerability to early adversity in rhesus macaques
TLDR
Data identify BDNF and NGF as neuroendocrine markers underlying differential responses to maternal deprivation in males and females rhesus macaques and identify the greater vulnerability to mood disorders of this gender reported in humans.
Falling in love is associated with immune system gene regulation
TLDR
To characterize the impact of romantic love on human genome function, genome-wide transcriptome profiling of circulating immune cell samples collected from 47 young women revealed a selective alteration in immune cell gene regulation characterized by up-regulation of Type I interferon response genes associated with CD1C+/BDCA-1+ dendritic cells (DCs) and CLEC4C-2+ DCs.
The Science of Love: State of the Art.
TLDR
It is proposed that the early stage of love, generally called romantic love, is the result of the activation of the brain limbic structures regulating fear/anxiety reactions leading to changes of major neurotransmitters, such as increased monoamine levels and decreased serotonin concentrations.
Emotions relating to romantic love-further disruptors of adolescent sleep.
TLDR
It is concluded that romantic love is one further cause for short or poor quality sleep in girls and may relate to symptoms of depression and anxiety in both sexes, however, feelings of infatuation contain important developmental lessons.
Stress, anxiety and schizophrenia and neurotrophic factors: the pioneer studies with nerve growth factor.
TLDR
Past and ongoing studies on neurotrophin (NT) role, in particular focusing on nerve growth factor (NGF), on behavioral response to stress, agonistic and emotional behavior, anxiety, and schizophrenia are highlighted.
Significantly lower nerve growth factor levels in patients with major depressive disorder than in healthy subjects: a meta-analysis and systematic review
TLDR
The main result was that the NGF levels were significantly lower in MDD than in HCs and that this had an inverse correlation with mean age and disease severity.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
Alteration of the platelet serotonin transporter in romantic love.
TLDR
The main finding of the present study is that subjects who were in the early romantic phase of a love relationship were not different from OCD patients in terms of the density of the platelet 5-HT transporter, which proved to be significantly lower than in the normal controls.
Emotional stress induced by parachute jumping enhances blood nerve growth factor levels and the distribution of nerve growth factor receptors in lymphocytes.
TLDR
Observations suggest that the release of NGF might be involved in the activation of cells of the immune system and is most probably associated with homeostatic adaptive mechanisms, as previously shown for stressed rodents.
Hormonal changes when falling in love
TLDR
The findings of the present study would indicate that to fall in love provokes transient hormonal changes some of which seem to be specific to each sex.
Psychosocial vs. “physical” stress situations in rodents and humans Role of neurotrophins
TLDR
The aim of this review is to outline the current understanding of the roles of NGF and BDNF in stress-related physiological changes in vertebrates, in particular for physical vs. psychological stressors, and summarize recent efforts to derive pharmacological strategies from the increasing body of BDNF and NGF neurobehavioral data.
Changes in plasma nerve growth factor levels in older adults associated with chronic stress
TLDR
Data suggest that exposure to this chronic stressor, caregiving for a cognitively impaired spouse, can alter the concentrations of circulating NGF, and that psychological stress can induce changes in NGF concentrations in older adults.
Epigenetic control of neurobehavioural plasticity: the role of neurotrophins
TLDR
Results have been extended to humans, showing that NGF levels are enhanced by emotional stress induced by parachute jumping, and suggest a role of neurotrophins as factors mediating both short- and long-term effects of experience on brain structure and function.
Kissing reduces allergic skin wheal responses and plasma neurotrophin levels
TLDR
Kissing significantly reduced wheal responses induced by HDM and JCP, but not by histamine, and decreased plasma levels of NGF, BDNF, NT-3, and NT-4 in patients with AR or AD, while it failed to do so in normal subjects, indicate that kissing have some implication in the study of neuroimmunology in allergic patients.
Reward, motivation, and emotion systems associated with early-stage intense romantic love.
TLDR
The results suggest that romantic love uses subcortical reward and motivation systems to focus on a specific individual, that limbic cortical regions process individual emotion factors, and that there is localization heterogeneity for reward functions in the human brain.
The neural basis of romantic love
TLDR
The activity in the brains of 17 subjects who were deeply in love was scanned using fMRI, suggesting that a unique network of areas is responsible for evoking this affective state, and postulate that the principle of functional specialization in the cortex applies to affective states as well.
Nerve growth factor serum concentrations in healthy human volunteers: physiological variance and stability
TLDR
Stability of the repetitive measurements over 4 weeks of NGF suggests that this neurotrophin may be an intraindividually solid marker at least in human serum.
...
1
2
3
4
5
...