Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress.

@article{Horvth1998RaisedLO,
  title={Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress.},
  author={Ildik{\'o} Horv{\'a}th and Louise E Donnelly and Andr{\'a}s Kiss and Paolo Paredi and Sergei A. Kharitonov and Peter J Barnes},
  journal={Thorax},
  year={1998},
  volume={53 8},
  pages={668-72}
}
BACKGROUND Chronic inflammatory diseases are associated with an increased production of oxidants. Induction of a stress protein, heme oxygenase (HO) HO-1, is a cytoprotective mechanism against oxidative cellular injury. HO-1 catabolises heme to bilirubin, free iron, and carbon monoxide (CO). METHODS Exhaled CO and sputum bilirubin levels were measured and HO-1 protein expression in airway macrophages was determined by Western blotting in asthmatic patients as levels of oxidants are raised in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 106 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 18 references

Oxidative stress in chronic obstructive pulmonary disease . Oxidative Stress Study Group

  • PJ Barnes
  • Am J Respir Crit Care Med
  • 1997

The elevated level of exhaled nitric oxide in asthmatic patients is mainly derived from the lower respiratory tract

  • PJ Lee, J Alam, SL Sylvester
  • Am J Respir Crit Care Med
  • 1996

Reactive oxygen species and iron : a dangerous partnership in inflammation

  • D Willis, AR Moore, R Frederick
  • Int J Biochem Cell Biol
  • 1995

Similar Papers

Loading similar papers…