RagD gene expression and NRF2 mutations in lung squamous cell carcinomas.

@article{Sasaki2012RagDGE,
  title={RagD gene expression and NRF2 mutations in lung squamous cell carcinomas.},
  author={Hidefumi Sasaki and Masayuki Shitara and Keisuke Yokota and Y U Hikosaka and Satoru Moriyama and Motoki Yano and Yoshitaka Fujii},
  journal={Oncology letters},
  year={2012},
  volume={4 6},
  pages={1167-1170}
}
RagD is a member of the small G protein family, which encodes a recently discovered activator of the mTOR pathway. In vitro, RagD plays an important role in the proliferation of NRF2 gene (NFE2L2) mutated cancer cells. We hypothesized that tumor RagD expression may be correlated with the mutation status of NRF2 in lung cancers. RagD mRNA levels were analyzed by quantitative real-time polymerase chain reaction (qPCR) in 90 surgically-treated lung squamous cell cancer cases, including 14 NRF2… CONTINUE READING