Raf regulates positive selection.

  title={Raf regulates positive selection.},
  author={Clodagh C O'Shea and Tessa Crompton and Ian R. Rosewell and Adrian C. Hayday and Michael J Owen},
  journal={European journal of immunology},
  volume={26 10},
T cell development is regulated by extracellular signals that mediate cellular proliferation and differentiation via specific signal transduction pathways. To determine the importance of the mitogen-activated protein kinase (MAP kinase) pathway in thymocyte development, we analyzed transgenic mice expressing dominant negative Raf (DN Raf) and a constitutively active v-Raf under the control of the p56lck proximal promoter. DN Raf had a profound effect on T cell receptor (TCR)-mediated signaling… CONTINUE READING


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