Raf kinase inhibitory protein inhibits beta-cell proliferation.

  title={Raf kinase inhibitory protein inhibits beta-cell proliferation.},
  author={Lizhi Zhang and Zheng Fu and Charles E. Binkley and Thomas J. Giordano and Charles F. Burant and Craig D. Logsdon and Diane M Simeone},
  volume={136 3},
BACKGROUND Raf-1 kinase inhibitory protein (RKIP) was recently identified as a physiologic endogenous inhibitor of the extracellular signal-regulated kinase (ERK) pathway. The expression and role of RKIP within the pancreas are unknown. METHODS RKIP expression in normal pancreas and human insulinomas was examined by using paraffin-embedded sections. Co-localization of RKIP within islet cell subtypes was performed by using double immunofluorescence staining with antibodies directed toward RKIP… CONTINUE READING


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