Raf kinase inhibitor protein regulation of raf and MAPK signaling.

@article{Hagan2006RafKI,
  title={Raf kinase inhibitor protein regulation of raf and MAPK signaling.},
  author={Suzanne Hagan and Rey Garcia and Amardeep Singh Dhillon and Walter Kolch},
  journal={Methods in enzymology},
  year={2006},
  volume={407},
  pages={248-59}
}
The Raf kinase inhibitor protein (RKIP) belongs to an evolutionarily conserved family of phosphatidylethanolamine-binding proteins (PEBPs), which have important functions as inhibitors of kinase signaling pathways and metastasis. Most notably, RKIP can interrupt signaling through the Ras-Raf-MEK-ERK pathway by dissociating the interaction between Raf-1 and its substrate MEK, highlighting the importance of protein interactions as regulatory interfaces. Furthermore, RKIP was shown to inhibit… CONTINUE READING