Raf-1 kinase and ERK2 uncoupled from mitogenic signals in rat fibroblasts.

@article{Kortenjann1995Raf1KA,
  title={Raf-1 kinase and ERK2 uncoupled from mitogenic signals in rat fibroblasts.},
  author={M Kortenjann and Peter E. Shaw},
  journal={Oncogene},
  year={1995},
  volume={11 10},
  pages={2105-12}
}
The MAP kinase pathway impinging on ERK2 has been shown to be integrally associated with mitogenic signalling in many cell types. Previously, we and others have demonstrated that oncogenic forms of Raf-1 kinase, when expressed in fibroblasts, lead to the constitutive activation of ERK2, the de-regulation of c-fos expression and increased cell proliferation. Here we describe an exception to this scenario. In Rat6 cells, although both ERK1 and ERK2 are activated in response to mitogens that… CONTINUE READING