Raf-1 activates MAP kinase-kinase

@article{Kyriakis1992Raf1AM,
  title={Raf-1 activates MAP kinase-kinase},
  author={John M. Kyriakis and Harald App and Xian-feng Zhang and Papia Banerjee and David L. Brautigan and Ulf R{\"u}diger Rapp and Joseph Avruch},
  journal={Nature},
  year={1992},
  volume={358},
  pages={417-421}
}
THE normal cellular homologue of the acutely transforming oncogene v-ra/is c-raf-l, which encodes a serine/threonine protein kinase that is activated by many extracellular stimuli1. The physiological substrates of the protein c-Raf-1 are unknown. The mitogen-activated protein (MAP) kinases ErkI and 2 are also activated by mitogens through phosphorylation of Erk tyrosine and threonine residues catalysed by a protein kinase of relative molecular mass 50,000, MAP kinase-kinase (MAPK-K)2–7. Here we… 
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Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells (*)
TLDR
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MEKK1 Binds Raf-1 and the ERK2 Cascade Components*
TLDR
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TLDR
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TLDR
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TLDR
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