Raf-1: a novel cardiac troponin T kinase

  title={Raf-1: a novel cardiac troponin T kinase},
  author={Paul J. Pfleiderer and Marius P. Sumandea and Vitalyi O. Rybin and Chaojian Wang and Susan F. Steinberg},
  journal={Journal of Muscle Research and Cell Motility},
Phosphorylation of cardiac troponin is a key mechanism involved in regulation of contractile function. In vitro kinase assays revealed that lysates prepared from resting cardiomyocytes contain cardiac troponin I (cTnI) and cTnT kinase activity. cTnI phosphorylation is inhibited by pharmacologic inhibitors of PKA, PKC, Rho kinase and PKC effectors such as… CONTINUE READING