Raf/MEK/ERK signalling triggers reactivation of Kaposi's sarcoma-associated herpesvirus latency.

@article{Ford2006RafMEKERKST,
  title={Raf/MEK/ERK signalling triggers reactivation of Kaposi's sarcoma-associated herpesvirus latency.},
  author={Patrick W. Ford and Benjaman A Bryan and Ossie F. Dyson and Douglas A. Weidner and Vishnu Chintalgattu and Shaw M Akula},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 5},
  pages={
          1139-44
        }
}
Kaposi's sarcoma-associated herpesvirus (KSHV) causes Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. KSHV infection of cells produces both latent and lytic cycles of infection. In vivo, the virus is found predominantly in the latent state. In vitro, a lytic infection can be induced in KSHV-infected cells by treating with phorbol ester (TPA). However, the exact signalling events that lead to the reactivation of KSHV lytic infection are still elusive. Here, a… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers.

  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2005
VIEW 3 EXCERPTS