Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation.

@article{Hochbaum2011RadixinAC,
  title={Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation.},
  author={Daniel R. Hochbaum and Guillermo O. Barila and Fernando Ribeiro-Neto and Daniel L. Altschuler},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 1},
  pages={859-66}
}
cAMP is an ubiquitous second messenger. Localized areas with high cAMP concentration, i.e. cAMP microdomains, provide an elegant mechanism to generate signaling specificity and transduction efficiency. However, the mechanisms underlying cAMP effector targeting into these compartments is still unclear. Here we report the identification of radixin as a… CONTINUE READING