Radiotoxicity of some iodine-123, iodine-125 and iodine-131-labeled compounds in mouse testes: implications for radiopharmaceutical design.

@article{Narra1992RadiotoxicityOS,
  title={Radiotoxicity of some iodine-123, iodine-125 and iodine-131-labeled compounds in mouse testes: implications for radiopharmaceutical design.},
  author={Venkat R Narra and Roger W. Howell and Ravi S Harapanhalli and Kasibhatia Sastry and Dandamudi V Rao},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1992},
  volume={33 12},
  pages={2196-201}
}
In this work, spermhead survival in mouse testis was used to investigate the radiotoxicity of several intratesticularly localized radioiodinated pharmaceuticals. Radioiodines that decay by electron capture and/or internal conversion (123I, 125I) as well as by beta- decay (131I) were coupled to pharmaceuticals that selectively localize in different cell compartments. Dose response curves yield D37 values of 62 cGy, 75 cGy, 61 cGy and 7.7 cGy for 123IMP (N-isopropyl-p-iodoamphetamine), 131IdU… CONTINUE READING