Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group.

@article{Vernon1996RadiotherapyWO,
  title={Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group.},
  author={ClareC. Vernon and Jeffrey W. Hand and Stuart B. Field and David Machin and Joan Whaley and Jacoba van der Zee and Wim L J van Putten and Gerard C. van Rhoon and Jan D. P. van Dijk and Dionisio Gonzalez Gonzalez and Fei ‐ Fei Liu and Poll Goodman and Michael Sherar},
  journal={International journal of radiation oncology, biology, physics},
  year={1996},
  volume={35 4},
  pages={
          731-44
        }
}
PURPOSE Claims for the value of hyperthermia as an adjunct to radiotherapy in the treatment of cancer have mostly been based on small Phase I or II trials. To test the benefit of this form of treatment, randomized Phase III trials were needed. METHODS AND MATERIALS Five randomized trials addressing this question were started between 1988 and 1991. In these trials, patients were eligible if they had advanced primary or recurrent breast cancer, and local radiotherapy was indicated in preference… CONTINUE READING
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