Radiotherapy with concurrent or sequential temozolomide in elderly patients with glioblastoma multiforme

@article{Hashem2012RadiotherapyWC,
  title={Radiotherapy with concurrent or sequential temozolomide in elderly patients with glioblastoma multiforme},
  author={Sameh A Hashem and Ahmed Salem and Abdullah Al-rashdan and Najeeb Ezam and Alaa Ahmad Nour and Amer Alsharbaji and Chandrababu Rejeeth and Issa Mohamad and Maher A. Sughayer and Maher Elyan and Maysa Al-Hussaini and Ala' Addasi and Abdelatif Almousa},
  journal={Journal of Medical Imaging and Radiation Oncology},
  year={2012},
  volume={56}
}
Objective: The objective of this article was to evaluate therapeutic outcomes of elderly patients with glioblastoma multiforme (GBM) treated by surgery followed by combined modality therapy and compare achievable outcomes to those of a younger age population. 
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Surgery for Glioblastoma in Elderly Patients.
Radiotherapy Plus Concurrent or Sequential Temozolomide for Glioblastoma in the Elderly: A Meta-Analysis
TLDR
A meta-analysis of nonrandomized studies provided level 2a evidence (Oxford Centre for Evidence-Based Medicine) that combined RT/TMZ conferred a clear survival benefit on a selection of elderly GBM patients who had a favorable prognosis.
Elderly patients with glioblastoma multiforme treated with concurrent temozolomide and standard- versus abbreviated-course radiotherapy.
TLDR
Elderly patients with multiple poor prognostic factors given ART had short survival times, and MGMT status may not predict outcome for these patients, relative to other variables.
Impact of standard care on elderly glioblastoma patients.
TLDR
The data suggests that, despite having a worse global prognostic than their younger counterparts, GBM patients ≥70yo with a good performance status could be treated according to the Stupp protocol with similar survival.
Survival Outcomes of Elderly Patients With Glioblastoma Multiforme in Their 75th Year or Older Treated With Adjuvant Therapy.
Radiotherapy in Glioblastoma: the Past, the Present and the Future.
Elderly patients aged 65–75 years with glioblastoma multiforme may benefit from long course radiation therapy with temozolomide
TLDR
Improved MS in the elderly population when TMZ is added to RT is demonstrated and those in the age group 65–75 may benefit from long-course RT with TMZ.
Biopsy versus resection in the management of high-grade gliomas in the elderly.
TLDR
The authors concluded that maximum resections are safe and are associated with longer survival time, delayed tumor progression rates, and improved functional recovery, and that increasing extents of tumor resection areassociated with improved outcomes.
Treatment outcomes in glioblastoma patients aged 76 years or older: a multicenter retrospective cohort study
TLDR
It is suggested that postoperative KPS score is an important prognostic factor for glioblastoma patients aged ≥76 years, and that these patients may benefit from temozolomide therapy.
Gross Total vs. Subtotal Resection on Survival Outcomes in Elderly Patients With High-Grade Glioma: A Systematic Review and Meta-Analysis
TLDR
GTR seems to be more effective than STR in achieving longer survival in elderly patients with high-grade glioma, according to this meta-analysis.
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