Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial

  title={Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial},
  author={R. Oliver and M. Mason and G. Mead and H. V. D. Maase and G. Rustin and J. Joffe and R. Wit and N. Aass and J. Graham and R. Coleman and S. Kirk and S. Stenning},
  journal={The Lancet},
  • R. Oliver, M. Mason, +9 authors S. Stenning
  • Published 2005
  • Medicine
  • The Lancet
  • BACKGROUND Adjuvant radiotherapy is effective treatment for stage I seminoma, but is associated with a risk of late non-germ-cell cancer and cardiovascular events. [...] Key MethodMETHODS Between 1996 and 2001, 1477 patients from 70 hospitals in 14 countries were randomly assigned to receive radiotherapy (para-aortic strip or dog-leg field; n=904) or one injection of carboplatin (n=573; dose based on the formula 7x[glomerular filtration rate+25] mg), at two trial centres in the UK and Belgium.Expand Abstract
    288 Citations

    Paper Mentions

    RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells… Expand
    ConditionsTesticular Germ Cell Tumor
    InterventionDrug, Radiation
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