Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

  title={Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.},
  author={Roger Stupp and Warren P. Mason and Martin J. van den Bent and Michael Weller and Barbara Jean Fisher and Martin J. B. Taphoorn and Karl B{\'e}langer and Alba A Brandes and Christine Marosi and U. Bogdahn and Juergen Curschmann and Robert Charles Janzer and Samuel K. Ludwin and Thierry Gorlia and Anouk Allgeier and Denis Lacombe and J. Gregory Cairncross and Elizabeth Eisenhauer and Ren{\'e} Olivier Mirimanoff},
  journal={The New England journal of medicine},
  volume={352 10},
BACKGROUND Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety. METHODS Patients with newly diagnosed, histologically confirmed glioblastoma were randomly… CONTINUE READING
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