Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck.

@article{Bonner2006RadiotherapyPC,
  title={Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck.},
  author={J. Bonner and P. Harari and J. Giralt and N. Azarnia and D. Shin and R. Cohen and C. Jones and R. Sur and D. Raben and J. Jassem and R. Ove and M. Kies and J. Baselga and H. Youssoufian and N. Amellal and E. Rowinsky and K. Ang},
  journal={The New England journal of medicine},
  year={2006},
  volume={354 6},
  pages={
          567-78
        }
}
  • J. Bonner, P. Harari, +14 authors K. Ang
  • Published 2006
  • Medicine
  • The New England journal of medicine
  • BACKGROUND We conducted a multinational, randomized study to compare radiotherapy alone with radiotherapy plus cetuximab, a monoclonal antibody against the epidermal growth factor receptor, in the treatment of locoregionally advanced squamous-cell carcinoma of the head and neck. [...] Key MethodMETHODS Patients with locoregionally advanced head and neck cancer were randomly assigned to treatment with high-dose radiotherapy alone (213 patients) or high-dose radiotherapy plus weekly cetuximab (211 patients) at…Expand Abstract

    Paper Mentions

    OBSERVATIONAL CLINICAL TRIAL
    Head and neck cancers account for the sixth leading cause of cancers worldwide. The annual incidence of Head and neck cancers is more than 650,000 the patients each year. Head and neck… Expand
    ConditionsHead and Neck Cancer
    InterventionOther
    INTERVENTIONAL CLINICAL TRIAL
    Background: Locally advanced head and neck cancer (HNC) is a challenge as, in spite of initial good control with chemoradiation, the majority of patients fails systemically. In the… Expand
    ConditionsLocally Advanced Head and Neck Cancer
    InterventionDrug
    INTERVENTIONAL CLINICAL TRIAL
    A phase III trial of induction chemotherapy followed by definitive radiotherapy plus Cetuximab versus chemoradiation in unresectable, locally advanced, squamous cell carcinoma of… Expand
    ConditionsSquamous Cell Carcinoma of the Head and Neck
    InterventionDrug, Radiation

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