Radiotherapy in the treatment of mucosal melanoma of the upper aerodigestive tract: analysis of 74 cases. A Rare Cancer Network study.

Abstract

PURPOSE To retrospectively analyze a series of mucosal melanoma of the upper aerodigestive tract to determine the prognostic factors and contribute to understanding the role of radiotherapy in the therapeutic strategy. METHODS AND MATERIALS Seventy-four patients were analyzed. The most frequent locations were nasal and oral, in 31 patients (41.9%) and 12 patients (16.2%), respectively. Sixty-three patients (85.1%) were in Stage I, 5 (6.8%) in Stage II, and 6 (8.1%) in Stage III. Treatment consisted of surgery in 17 patients (23.0%), surgery and radiotherapy in 42 (56.8%), radiotherapy in 11 (14.9%), and chemo-immunotherapy in 4 (5.4%). Median follow-up was 20 months. RESULTS Local control at 3 years was 57% after surgery alone and 71% after surgery and radiotherapy. Overall and disease-free survival rates, respectively, were 41% and 31% at 3 years and 14% and 22% at 10 years. After univariate analysis, female gender, melanosis, tumor size </=3 cm, Stage I, postoperative radiotherapy, and complete remission were favorable prognostic factors. Stage I and melanosis were confirmed by multivariate analysis. CONCLUSIONS Local control was improved by postoperative radiotherapy, despite survival being as poor as in other published series. Stage I and melanosis at diagnosis were the most favorable prognostic factors.

050010002008200920102011201220132014201520162017
Citations per Year

2,717 Citations

Semantic Scholar estimates that this publication has 2,717 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Krengli2006RadiotherapyIT, title={Radiotherapy in the treatment of mucosal melanoma of the upper aerodigestive tract: analysis of 74 cases. A Rare Cancer Network study.}, author={Marco Krengli and Laura Masini and Johannes H. A. M. Kaanders and Philippe Maingon and Swan Bing Oei and Abderrahim Zouhair and Enis Ozyar and Martine Roelandts and Maurizio Amichetti and Mathieu Bosset and Ren{\'e}-Olivier Mirimanoff}, journal={International journal of radiation oncology, biology, physics}, year={2006}, volume={65 3}, pages={751-9} }