Radiotherapy enhancement with gold nanoparticles.

@article{Hainfeld2008RadiotherapyEW,
  title={Radiotherapy enhancement with gold nanoparticles.},
  author={James F. Hainfeld and Farrokh Avraham Dilmanian and Daniel N. Slatkin and Henry M. Smilowitz},
  journal={The Journal of pharmacy and pharmacology},
  year={2008},
  volume={60 8},
  pages={
          977-85
        }
}
  • James F. Hainfeld, Farrokh Avraham Dilmanian, +1 author Henry M. Smilowitz
  • Published in
    The Journal of pharmacy and…
    2008
  • Medicine, Chemistry
  • Gold is an excellent absorber of X-rays. If tumours could be loaded with gold, this would lead to a higher dose to the cancerous tissue compared with the dose received by normal tissue during a radiotherapy treatment. Calculations indicate that this dose enhancement can be significant, even 200% or greater. In this paper, the physical and biological parameters affecting this enhancement are discussed. Gold nanoparticles have shown therapeutic efficacy in animal trials and these results are… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Figures and Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 245 CITATIONS, ESTIMATED 59% COVERAGE

    A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

    VIEW 6 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Radio-Enhancing Properties of Bimetallic Au:Pt Nanoparticles: Experimental and Theoretical Evidence

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Gold nanoparticle conjugates: recent advances toward clinical applications.

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Gold Nanoparticles for Radiation Enhancement in Vivo.

    VIEW 7 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    2009
    2020

    CITATION STATISTICS

    • 14 Highly Influenced Citations

    • Averaged 26 Citations per year from 2017 through 2019

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 38 REFERENCES

    The influence of energy absorption and electron range on dosage in irradiated bone.

    • F. W. Spiers
    • Mathematics, Medicine
    • The British journal of radiology
    • 1949
    VIEW 5 EXCERPTS
    HIGHLY INFLUENTIAL

    Gold nanoparticles: a new X-ray contrast agent.

    • Moshi Geso
    • Medicine
    • The British journal of radiology
    • 2007
    VIEW 1 EXCERPT
    HIGHLY INFLUENTIAL

    First radiotherapy of human metastatic brain tumors delivered by a computerized tomography scanner (CTRx).

    VIEW 2 EXCERPTS
    HIGHLY INFLUENTIAL

    Radiosensitization by a new potent nucleoside analog: 1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole(RP-343).

    VIEW 1 EXCERPT
    HIGHLY INFLUENTIAL