Radiotherapy enhancement with gold nanoparticles
@article{Hainfeld2008RadiotherapyEW, title={Radiotherapy enhancement with gold nanoparticles}, author={James F. Hainfeld and F. Avraham Dilmanian and Daniel N Slatkin and Henry M Smilowitz}, journal={Journal of Pharmacy and Pharmacology}, year={2008}, volume={60} }
Gold is an excellent absorber of X‐rays. If tumours could be loaded with gold, this would lead to a higher dose to the cancerous tissue compared with the dose received by normal tissue during a radiotherapy treatment. Calculations indicate that this dose enhancement can be significant, even 200% or greater. In this paper, the physical and biological parameters affecting this enhancement are discussed. Gold nanoparticles have shown therapeutic efficacy in animal trials and these results are…
611 Citations
Gold nanoparticle hyperthermia reduces radiotherapy dose.
- Medicine, PhysicsNanomedicine : nanotechnology, biology, and medicine
- 2014
The enhancement of prostate cancer treatment using gold nanoparticles and high energy photons
- Physics
- 2013
Gold nanoparticles (AuNPs) are widely used for medical applications, because it ability to convert as colloidal solution, have no interaction with biotic tissue, low toxicity, easy in the detection,…
Gold nanoparticles for cancer radiotherapy: a review
- PhysicsCancer Nanotechnology
- 2016
The mechanisms of action of radiation therapy with photons and ions in the presence and absence of nanoparticles, as well as the influence of some of the core and coating design parameters of nanop particles on their radiosensitisation capabilities are summarised.
Metal-enhanced radiotherapy: Gold nanoparticles and beyond
- Medicine2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)
- 2015
More clinical studies are needed to verify these promising results in clinical setting as well as combination of RT-NP with either classical chemotherapy or targeted agents and other cancer treatments (hyperthermia, photodynamic therapy).
Gold Nanoparticles in Radiotherapy and Recent Progress in Nanobrachytherapy
- Physics, MedicineAdvanced healthcare materials
- 2018
This review describes the main mechanisms occurring between photons and GNPs that lead to dose enhancement and the findings of the most recent in vivo studies about interactions between GNPs and photon sources.
Targeted Gold Nanocluster-Enhanced Radiotherapy of Prostate Cancer.
- Medicine, PhysicsSmall
- 2019
Targeted-Au25 NCs are rapidly and selectively taken up by prostate cancer in vitro and in vivo and also have fast renal clearance and may allow reductions in radiation dose, decreasing exposure to healthy tissue and making them highly attractive for clinical translation.
Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment
- Medicine, BiologyNanoscale Research Letters
- 2016
It is proposed that GNCs can be used for clinical treatment and to potentially overcome resistance to radiotherapy by clearly increasing the antitumor effect.
Enhancing Radiotherapy Using Ultrasound And Microbubbles With Gold Nanoparticles
- Physics, Medicine
- 2021
The results suggest that AuNPs, and USMB aid in its delivery to increase cell death upon irradiation, implying synergism.
Gold nanoparticles for radiosensitizing and imaging of cancer cells
- Medicine, PhysicsRadiation Physics and Chemistry
- 2018
Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma
- Physics, MedicinePhysics in medicine and biology
- 2010
It is concluded that gold nanoparticles enhance the radiation therapy of a radioresistant mouse squamous cell carcinoma, thereby further reducing TCD50 s (tumor control dose 50%) and increasing long-term survivals.
References
SHOWING 1-10 OF 43 REFERENCES
The use of gold nanoparticles to enhance radiotherapy in mice.
- MedicinePhysics in medicine and biology
- 2004
This novel use of small gold nanoparticles permitted achievement of the high metal content in tumours necessary for significant high-Z radioenhancement in mice bearing subcutaneous EMT-6 mammary carcinomas.
Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study.
- Physics, MedicinePhysics in medicine and biology
- 2005
This preliminary study estimated this dose enhancement by Monte Carlo calculations for several phantom test cases representing radiation treatments with the following modalities: 140 kVp x-rays, 4 and 6 MV photon beams, and 192Ir gamma rays.
Gold microspheres: a selective technique for producing biologically effective dose enhancement.
- Medicine, PhysicsInternational journal of radiation biology
- 2000
An increased biologically effective dose can be produced by gold microspheres suspended in cell culture or distributed in tumour tissue exposed to kilovoltage photon beams, with the increasing use of interstitial brachytherapy with isotopes that produce low-energy photons.
Gold nanoparticles: a new X-ray contrast agent.
- Medicine, BiologyThe British journal of radiology
- 2006
Gold nanoparticles can be used as X-ray contrast agents with properties that overcome some significant limitations of iodine-based agents, and this report is the first demonstration that gold nanoparticles may overcome these limitations.
Characterization of the Theorectical Radiation Dose Enhancement from Nanoparticles
- Physics, MedicineTechnology in cancer research & treatment
- 2007
High atomic number nanoparticles coupled with low energy external beam x-rays or brachytherapy sources offer the potential of significantly enhancing the delivered dose.
Radiation dose enhancement in tumors with iodine.
- Medicine, PhysicsMedical physics
- 1983
There may be a therapeutic advantage from loading tumors with iodine and treating them with low-energy photons, according to the results of this study.
The influence of energy absorption and electron range on dosage in irradiated bone.
- Medicine, PhysicsThe British journal of radiology
- 1949
The results of the calculations suggest that the tolerance dose of the soft tissue elements in bone may be only one half of that of soft tissues in other situations, and for medium voltage and superficial X rays this relative tolerance may be no more than one-third.
First radiotherapy of human metastatic brain tumors delivered by a computerized tomography scanner (CTRx).
- Medicine, PhysicsInternational journal of radiation oncology, biology, physics
- 1999
Optimal photon energies for IUdR K-edge radiosensitization with filtered x-ray and radioisotope sources.
- Physics, MedicinePhysics in medicine and biology
- 1999
The results support the clinical application of IUdR and low-energy brachytherapy, perhaps using new technologies such as the x-ray needle or new isotopes such as Yb-169.
Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy.
- MedicineInternational journal of radiation oncology, biology, physics
- 2006