Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors.

@article{Chen2009RadiotherapyDV,
  title={Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors.},
  author={F Y Chen and C M Chiang and Chun-Chieh Wang and C S Tsai and Shih-Ming Jung and Chung-Chi Lee and William H. Mcbride and Ji-Hong Hong},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 5},
  pages={1721-9}
}
PURPOSE To investigate how single or fractionated doses of radiation change the microenvironment in transgenic adenocarcinoma of the mouse prostate (TRAMP)-C1 tumors with respect to vascularity, hypoxia, and macrophage infiltrates. EXPERIMENTAL DESIGN Murine prostate TRAMP-C1 tumors were grown in C57BL/6J mice to 4 mm tumor diameter and were irradiated with either 25 Gy in a single dose or 60 Gy in 15 fractions. Changes in vascularity, hypoxia, and macrophage infiltrates were assessed by… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 42 references

Angiogen - esis with pericyte abnormalities in a transgenic model of prostate carcinoma

YaoVJ Ozawa MG, ChantheryYH
Cancer • 2005

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