Radiotherapy combined with the immunocytokine L19-IL2 provides long-lasting antitumor effects.

@article{Zegers2015RadiotherapyCW,
  title={Radiotherapy combined with the immunocytokine L19-IL2 provides long-lasting antitumor effects.},
  author={Catharina M. L. Zegers and Nicolle H. Rekers and Dana H F Quaden and Natasja Gaby Lieuwes and Ala Yaromina and Wilfred T. V. Germeraad and Lotte Wieten and Erik A. L. Biessen and Louis Boon and Dario Neri and Esther G. C. Troost and Ludwig Dubois and Philippe Lambin},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2015},
  volume={21 5},
  pages={1151-60}
}
PURPOSE Radiotherapy modifies the tumor microenvironment and causes the release of tumor antigens, which can enhance the effect of immunotherapy. L19 targets the extra domain B (ED-B) of fibronectin, a marker for tumor neoangiogenesis, and can be used as immunocytokine when coupled to IL2. We hypothesize that radiotherapy in combination with L19-IL2 provides an enhanced antitumor effect, which is dependent on ED-B expression. EXPERIMENTAL DESIGN Mice were injected with syngeneic C51 colon… CONTINUE READING
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