Radiotherapy combined with intratumoral dendritic cell vaccination enhances the therapeutic efficacy of adoptive T-cell transfer.

@article{TeitzTennenbaum2009RadiotherapyCW,
  title={Radiotherapy combined with intratumoral dendritic cell vaccination enhances the therapeutic efficacy of adoptive T-cell transfer.},
  author={Seagal Teitz-Tennenbaum and Qiao Li and Mary Alice Davis and Kari Wilder-Romans and Janet B Hoff and Mu J Li and Alfred E. Chang},
  journal={Journal of immunotherapy},
  year={2009},
  volume={32 6},
  pages={602-12}
}
Treatment of C57BL/6 mice with cyclophosphamide (100 mg/kg) and fludarabine (200 mg/kg) induced nonmyeloablative lymphodepletion without inhibiting D5 melanoma tumor growth. Using this model, we found that induction of lymphopenia before adoptive transfer of ex vivo anti-CD3/CD28 activated and interleukin-2 expanded D5-G6 tumor draining lymph node cells… CONTINUE READING