Radiotherapy and short-term androgen deprivation for localized prostate cancer.

  title={Radiotherapy and short-term androgen deprivation for localized prostate cancer.},
  author={Christopher U. Jones and Daniel P. Hunt and David G. McGowan and Mahul B. Amin and Michael P. Chetner and Deborah Watkins Bruner and Mark H. Leibenhaut and Siraj Husain and Marvin Z Rotman and Luis Souhami and Howard M. Sandler and William U. Shipley},
  journal={The New England journal of medicine},
  volume={365 2},
BACKGROUND It is not known whether short-term androgen-deprivation therapy (ADT) before and during radiotherapy improves cancer control and overall survival among patients with early, localized prostate adenocarcinoma. METHODS From 1994 through 2001, we randomly assigned 1979 eligible patients with stage T1b, T1c, T2a, or T2b prostate adenocarcinoma and a prostate-specific antigen (PSA) level of 20 ng per milliliter or less to radiotherapy alone (992 patients) or radiotherapy with 4 months of… 

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