Radiotargeted gene therapy.

  title={Radiotargeted gene therapy.},
  author={Donald J Buchsbaum and Tandra R. Chaudhuri and Kurt R. Zinn},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={46 Suppl 1},
The radiotargeted gene therapy approach to localizing radionuclides at tumor sites involves inducing tumor cells to synthesize a membrane-expressed receptor with a high affinity for injected radiolabeled ligands. A second strategy involves transduction of the sodium iodide symporter (NIS) and free radionuclide therapy. Using the first strategy, induction of high levels of human somatostatin receptor subtype 2 expression and selective tumor uptake, imaging, or growth inhibition with radiolabeled… CONTINUE READING


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