Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A.

@article{Plisson2011RadiosynthesisAI,
  title={Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A.},
  author={Christophe Plisson and Cristian Salinas and David Weinzimmer and David C Labaree and Shu-Fei Lin and Yu-Shin Ding and Steen Jakobsen and Paul W Smith and Kawanishi Eiji and Richard E. Carson and Roger N. Gunn and Eugenii A. Rabiner},
  journal={Nuclear medicine and biology},
  year={2011},
  volume={38 6},
  pages={875-84}
}
INTRODUCTION The aim of this study was to evaluate a newly reported positron emission tomography (PET) radioligand [(11)C]MP-10, a potent and selective inhibitor of the central phosphodiesterase 10A enzyme (PDE10A) in vivo, using PET. METHODS A procedure was developed for labeling MP-10 with carbon-11. [(11)C]MP-10 was evaluated in vivo both in the pig and baboon brain. RESULTS Alkylation of the corresponding desmethyl compound with [(11)C]methyl iodide produced [(11)C]MP-10 with good… CONTINUE READING

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