Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

@article{Ettrup2010RadiosynthesisAI,
  title={Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers},
  author={A. Ettrup and M. Hansen and M. A. Santini and J. Paine and N. Gillings and M. Palner and S. Lehel and M. Herth and J. Madsen and J. Kristensen and M. Begtrup and G. Knudsen},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2010},
  volume={38},
  pages={681-693}
}
  • A. Ettrup, M. Hansen, +9 authors G. Knudsen
  • Published 2010
  • Chemistry, Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging
  • PurposePositron emission tomography (PET) imaging of serotonin 2A (5-HT2A) receptors with agonist tracers holds promise for the selective labelling of 5-HT2A receptors in their high-affinity state. We have previously validated [11C]Cimbi-5 and found that it is a 5-HT2A receptor agonist PET tracer. In an attempt to further optimize the target-to-background binding ratio, we modified the chemical structure of the phenethylamine backbone and carbon-11 labelling site of [11C]Cimbi-5 in different… CONTINUE READING
    88 Citations

    Paper Mentions

    Interventional Clinical Trial
    The serotonin 2A (5-HT2A) receptor is the most abundant excitatory serotonin (5-HT, 5-hydroxytryptamine) receptor in the human brain, and multiple positron emission tomography (PET… Expand
    ConditionsHealthy
    InterventionDietary Supplement, Drug, Other
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