Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers
@article{Ettrup2010RadiosynthesisAI, title={Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers}, author={Anders Ettrup and Martin Hansen and Martin A. Santini and James Paine and Nic Gillings and Mikael Palner and Szabolcs Lehel and Matthias Manfred Herth and Jacob Madsen and Jesper L. Kristensen and Mikael Begtrup and Gitte Moos Knudsen}, journal={European Journal of Nuclear Medicine and Molecular Imaging}, year={2010}, volume={38}, pages={681-693} }
PurposePositron emission tomography (PET) imaging of serotonin 2A (5-HT2A) receptors with agonist tracers holds promise for the selective labelling of 5-HT2A receptors in their high-affinity state. We have previously validated [11C]Cimbi-5 and found that it is a 5-HT2A receptor agonist PET tracer. In an attempt to further optimize the target-to-background binding ratio, we modified the chemical structure of the phenethylamine backbone and carbon-11 labelling site of [11C]Cimbi-5 in different…
108 Citations
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The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions
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It is shown that small polar radiometabolites can substantially decrease the signal-to- Background ratio of PET radioligands for neuroimaging, and it is found that [11C]Cimbi-36 has a better signal- to-background ratio, and thus will be more sensitive to changes in 5-HT2A receptor levels in the brain.
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