• DOI:10.1007/s00259-010-1686-8
Corpus ID: 12467684

Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

@article{Ettrup2010RadiosynthesisAI,
  title={Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers},
  author={A. Ettrup and M. Hansen and M. A. Santini and J. Paine and N. Gillings and M. Palner and S. Lehel and M. Herth and J. Madsen and J. Kristensen and M. Begtrup and G. Knudsen},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2010},
  volume={38},
  pages={681-693}
}

A. Ettrup, M. Hansen, +9 authors G. Knudsen

Published 2010

Chemistry, Medicine

European Journal of Nuclear Medicine and Molecular Imaging

PurposePositron emission tomography (PET) imaging of serotonin 2A (5-HT2A) receptors with agonist tracers holds promise for the selective labelling of 5-HT2A receptors in their high-affinity state. We have previously validated [11C]Cimbi-5 and found that it is a 5-HT2A receptor agonist PET tracer. In an attempt to further optimize the target-to-background binding ratio, we modified the chemical structure of the phenethylamine backbone and carbon-11 labelling site of [11C]Cimbi-5 in different… CONTINUE READING

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