Corpus ID: 8546915

Radiosynthesis, in vitro validation, and in vivo evaluation of 18F-labeled COX-1 and COX-2 inhibitors.

@article{McCarthy2002RadiosynthesisIV,
  title={Radiosynthesis, in vitro validation, and in vivo evaluation of 18F-labeled COX-1 and COX-2 inhibitors.},
  author={Timothy J. McCarthy and Ahmed Sheriff and Matthew J. Graneto and John Jeffrey Talley and Michael J. Welch},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2002},
  volume={43 1},
  pages={
          117-24
        }
}
  • T. McCarthy, A. Sheriff, +2 authors M. Welch
  • Published 2002
  • Chemistry, Medicine
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
UNLABELLED In this article, we describe the radiosynthesis and evaluation of 18F-labeled cyclooxygenase (COX) inhibitors. 18F-SC63217 is selective to COX-1 and has a COX-1 inhibitory concentration of 50% (IC(50)) < 10 nmol/L and a COX-2 IC(50) > 100 micromol/L. 18F-SC58125 has IC(50) values of >100 micromol/L (COX-1) and <86 nmol/L (COX-2). METHODS SC63217 and SC58125 were both labeled with 18F by nucleophilic displacement of a trimethylammonium triflate salt using a dedicated microwave… Expand
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