Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.

@article{Carlson2009RadiosensitizingEO,
  title={Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.},
  author={Brett L. Carlson and Patrick Grogan and Ann C. Mladek and Mark A Schroeder and Gaspar J. Kitange and P. Anthony Decker and Caterina Giannini and Wenting Wu and Karla A Ballman and C. David James and Jann N. Sarkaria},
  journal={International journal of radiation oncology, biology, physics},
  year={2009},
  volume={75 1},
  pages={212-9}
}
PURPOSE Concurrent temozolomide (TMZ) and radiation therapy (RT) followed by adjuvant TMZ is standard treatment for patients with glioblastoma multiforme (GBM), although the relative contribution of concurrent versus adjuvant TMZ is unknown. In this study, the efficacy of TMZ/RT was tested with a panel of 20 primary GBM xenografts. METHODS AND MATERIALS Mice with intracranial xenografts were treated with TMZ, RT, TMZ/RT, or placebo. Survival ratio for a given treatment/line was defined as the… CONTINUE READING

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